Cancer Prevention, Information and ResearchThe following information was found at Annie Apple Seed Project ,a group of ALL volunteers working on informing the public about cancer and alternative ways to deal with the dreadful disease. They have been doing this for 10 years.
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One in eight women are affected with breast cancer. Ganoderma is showing promise in breast cancer treatment.
Ganoderma lucidum extract induces cell cycle arrest and apoptosis in MCF-7 human breast cancer cell. Hu H, Ahn NS, Yang X, Lee YS, Kang KS Department of Veterinary Public Health, College of Veterinary Medicine, Seoul National University, Korea. [Medline record in process] Although the pharmacology and clinical application of water extracts of Ganoderma lucidum have been extensively documented, little is known regarding its alcohol extract. In the present study, the anti-tumor effect of an alcohol extract of Ganoderma lucidum was investigated using MCF-7 cells We found that the alcohol extract of Ganoderma lucidum inhibited cell proliferation in a dose- and time-dependent manner, which might be mediated through up-regulation of p21/Waf1 and down-regulation of cyclin D1. Furthermore, this compound can directly induce apoptosis in MCF-7 cells, which might be mediated through up-regulation of a pro-apoptotic Bax protein and not by the immune system. Our findings suggest that there are multiple mechanisms underlying the anti-tumor effects of Ganoderma lucidum. Int J Cancer 2002 Nov 20;102(3):250-3 Copyright 2002 Wiley-Liss, Inc.
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